In the U.S. there are 17 million people with Major Depressive Disorder (MDD). As many as 30-40% of those people have a treatment-resistant form of the disorder (TRD). Nearly one half of those diagnosed with depression also have anxiety disorder and vice versa. The number of Americans with Post Traumatic Stress Disorder and Obsessive Compulsive Disorder are 7.7 million and 2.2 million Americans, respectively.
Ketamine is a dissociative anesthetic that has been used safely and extensively since FDA approval in 1970. Ketamine is also included on the WHO list of essential medications, due to its wide margin of safety across all age groups.
Ketamine works by binding to N-methyl-D-aspartate receptors causing a disinhibition pyramidal cells which cause increased Glutamate release. Multiple lines of research evidence also show that BDNF (brain derived nerve factor) serves a critical role in the pathogenesis of depression and ketamine’s rapid-acting effects are through the rapid BDNF synthesis pathway. Through functional imaging scans, ketamine appears to aid with depression by activating the anterior cingulate cortex and increasing connectivity between the insult and default mode network.
Ketamine infusion therapy can be effectively used as an off label treatment for various chronic conditions including depression, substance dependence, PTSD, OCD and Anxiety Disorder. There have been few advances in depression therapy in recent years, ketamine offers renewed hope.
Since 2000, low dose ketamine has been found to be highly successful for persons with treatment resistant forms of mood disorder. Individuals who have not responded to other antidepressants report a beneficial effect within hours. Ketamine treatment for TRD has been hailed as the most important breakthrough in antidepressant therapy in decades by the NIH. The Cleveland Clinic listed Ketamine for TRD as one of the Top 10 Medical Innovations in 2017.
The staff from AyaFusion Wellness Clinic now offer ketamine therapy as a viable treatment choice to relieve the suffering.
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