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The Ketamine Difference

Nov 11, 2020 8:32:11 AM

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At AyaFusion Wellness Clinic, you’ll be met by compassionate and caring medical experts who specialize in helping patients recover from depression with ketamine infusion therapy. If you have any questions, contact us! Here’s what you need to know about the differences between ketamine and antidepressants.


Ketamine and antidepressants both target brain chemicals that regulate your mood. The extraordinary value of ketamine lies in the way it differs from antidepressants. Ketamine produces different results depending on the dose. At high doses, ketamine serves as an anesthetic that’s used during surgery. Giving ketamine in a low dose, turns into an effective pain reliever and antidepressant.

If you struggle with depression, why wouldn't you want an antidepressant rather than an anesthetic? The answer to that question lies in the other differences between ketamine and antidepressants, like how well they lessen depression, how quickly they work, and their potential side effects.

Effectiveness of ketamine vs. antidepressants

Yes, there are patients that get great results from antidepressants. Realistically, only 70% find relief from traditional antidepressants. After a process of trial and error, even trying different types of antidepressants at varying doses, some patients still suffer from major depression.

When those with treatment-resistant depression begin taking low-dose ketamine treatments, between 50 and 70% experience a drastic improvement in their symptoms. Ketamine can produce results for patients with bipolar depression, major depression, and those who may be suicidal.

Rapid results

Even if your antidepressant works, it can take weeks to notice an improvement in your symptoms. After an intravenous (IV) infusion of ketamine, most patients experience the difference within hours.

Antidepressants and Ketamine both affect neurotransmitters that regulate your moods, but they do so very differently. Antidepressants target serotonin and dopamine, which takes weeks to help your depression.

Low-dose ketamine bypasses serotonin and dopamine and directly affects levels of a glutamate (a neurotransmitter that is released by nerve cells in the brain). Ketamine balances levels of glutamate quickly. Your mood improves and your depression symptoms are lifted!


By comparison, antidepressants are known for producing long lists of possible side effects, including nausea, diarrhea, headaches, weight gain, sexual dysfunction, anxiety, dizziness, dry mouth, and insomnia. If you develop these symptoms, your doctor may need to adjust your dose or switch to a different medication to get rid of the problem.

Since ketamine is a dissociative anesthetic, you may experience tingling or floating sensations, feel like you’re in a dream-like state, or develop dizziness, nausea, or blurry vision during your treatment. However, these side effects go away shortly after your treatment with ketamine.

You stay in the office for at least an hour following your ketamine session so we can monitor your health before sending you home. Beyond the immediate impact of the medication, low-dose ketamine has an impressive safety record. 

Contact Us

Do you need help with ongoing depression? Contact us to learn if you're a good candidate for ketamine treatments. 

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AyaFusion Wellness ClinicWe are a leading provider of Ketamine Infusions and IV Therapy Infusions.

We Provide Effective Treatment For The Following Conditions: Major Depressive Disorders, Post-traumatic Stress Disorder (PTSD), Bipolar Depression, Obsessive Compulsive Disorder (OCD), Chronic Migraines, Severe Anxiety, Fibromyalgia and Chronic Pain Syndromes. We also offer treatments to aid in energy boosts, hangover remedy, performance and recovery infusions, immunity boosters and more.


Written by Ayafusion